Figure 8.

Protandim marginally promotes differentiation of primary rat OPCs in the presence of TNF. After 2 days of de-differentiation, primary rat OPCs were incubated with 30 µg/mL Protandim or vehicle control (EtOH) for 24 h. After removal of medium, cells were subsequently exposed to either control medium or medium with 10 ng/mL TNF for 5 days. MBP and Olig2 expression were assayed by immunocytochemistry. Data are presented as percentage of control and expressed as the mean ± SEM of 3 independent experiments. Statistics reflect student’s t-test, one-tailed; * p < 0.05.