Figure 5. The central region of 11 cbEGF repeats of LTBP1 is flexible but held in an extended conformation by calcium.

(A) Array of models produced using EOM from the EGF region X-ray scattering data in the presence of calcium. Extended conformations are more prevalent. (B) Class averages from negative stain EM showing a range of conformations reflected in the SAXS models, which are unable to resolve to a single 3D model (box size = 44.8 nm).