Figure 7.

Histology and fluorescence confocal microscopy of tumor bearing liver tissues; H&E staining shows densely packed cells with abnormal nuclei and sharp transition from normal to malignant cells. Immunohistochemistry of the same samples show high MET expression in the tumor and no expression in the normal liver cells, magnification X10. Magnified view of the intrahepatic tumors demonstrates elevated expression of MET in the abnormal cells, magnification X400. Laser confocal imaging of frozen tissues showed a sharp tumor-liver margin with significantly increased MET probe uptake within the tumor compared to the adjacent background.