Table 2.
Summary of different kinetics parameters calculated from compartmental modeling for each sized AuNR. The parameter values for all individual mouse (M1 to M5 represent the mouse 1 to mouse 5 used for each size of AuNR) are presented with the mean and STD values for each group of AuNR size.
| Size (nmxnm) |
Mdiff | Blood half life (h) | Tumor AUC (%ID*h/g) |
Uptake @ 24 h (%ID/g) |
Uptake @ 48 h (%ID/g) |
Max uptake (%ID/g) |
K1 (h-1) | k2 (h-1) | VD | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| P1 | M1 | 2x10 | 0.055 | 12.78 | 288.9 | 5.92 | 5.31 | 7.80 | 0.25 | 0.089 | 2.77 |
| M2 | 17.99 | 210.9 | 5.00 | 4.65 | 5.00 | 0.10 | 0.044 | 2.28 | |||
| M3 | 15.01 | 242.7 | 6.20 | 5.15 | 6.20 | 0.17 | 0.069 | 2.48 | |||
| M4 | 18.06 | 260.6 | 5.51 | 5.70 | 5.70 | 0.13 | 0.092 | 1.44 | |||
| M5 | 15.52 | 187.5 | 4.11 | 4.32 | 4.32 | 0.15 | 0.105 | 1.42 | |||
| mean | 15.87 | 238.1 | 5.35 | 5.02 | 5.80 | 0.16 | 0.080 | 2.08 | |||
| STD | 1.11 | 20.02 | 0.41 | 0.27 | 0.90 | 0.03 | 0.012 | 0.31 | |||
| P4 | M1 | 10x37 | 0.012 | 17.05 | 2.10E+02 | 5.17 | 4.06 | 5.17 | 0.14 | 0.116 | 1.94 |
| M2 | 15.00 | 2.19E+02 | 5.19 | 4.59 | 5.19 | 0.21 | 0.083 | 3.58 | |||
| M3 | 12.84 | 1.73E+02 | 3.87 | 3.76 | 3.91 | 0.22 | 0.054 | 3.55 | |||
| M4 | 16.17 | 1.80E+02 | 4.22 | 4.11 | 4.22 | 0.22 | 0.070 | 2.56 | |||
| M5 | 13.92 | 1.95E+02 | 4.63 | 4.08 | 4.63 | 0.23 | 0.061 | 2.51 | |||
| mean | 15.00 | 195.4 | 4.62 | 4.12 | 4.62 | 0.20 | 0.075 | 2.83 | |||
| STD | 0.84 | 9.72 | 0.29 | 0.15 | 0.29 | 0.02 | 0.0105 | 0.36 | |||
| P2 | M1 | 13x40 | 0.009 | 11.26 | 197.3 | 4.65 | 3.81 | 4.69 | 0.20 | 0.110 | 1.94 |
| M2 | 11.87 | 170.5 | 4.22 | 3.25 | 4.22 | 0.29 | 0.069 | 3.93 | |||
| M3 | 12.82 | 244.2 | 5.85 | 5.00 | 5.85 | 0.19 | 0.097 | 2.90 | |||
| M4 | 9.62 | 149.1 | 3.40 | 2.82 | 3.96 | 0.18 | 0.086 | 2.78 | |||
| M5 | 13.28 | 218.5 | 4.99 | 4.27 | 4.99 | 0.15 | 0.071 | 2.52 | |||
| mean | 11.77 | 195.9 | 4.62 | 3.83 | 4.74 | 0.21 | 0.086 | 2.81 | |||
| STD | 0.72 | 18.9 | 0.45 | 0.43 | 0.45 | 0.03 | 0.008 | 0.36 | |||
| P3 | M1 | 13x70 | 0.008 | 7.00 | 201.4 | 4.50 | 3.86 | 4.64 | 0.21 | 0.053 | 2.53 |
| M2 | 8.55 | 294.9 | 6.59 | 5.35 | 7.06 | 0.27 | 0.066 | 3.12 | |||
| M3 | 7.85 | 264.0 | 5.95 | 3.91 | 6.83 | 0.28 | 0.107 | 2.09 | |||
| M4 | 8.625 | 227.3 | 4.85 | 4.80 | 4.98 | 0.24 | 0.128 | 1.72 | |||
| M5 | 10.50 | 171.2 | 3.67 | 3.53 | 3.76 | 0.18 | 0.139 | 1.61 | |||
| mean | 8.51 | 231.8 | 5.11 | 4.29 | 5.45 | 0.24 | 0.099 | 2.22 | |||
| STD | 0.65 | 24.5 | 0.58 | 0.38 | 0.75 | 0.02 | 0.019 | 0.31 | |||
| P5 | M1 | 18x45 | 0.006 | 5.14 | 218.8 | 5.00 | 3.73 | 5.14 | 0.35 | 0.100 | 3.49 |
| M2 | 5.01 | 179.8 | 4.02 | 3.41 | 4.18 | 0.49 | 0.181 | 2.70 | |||
| M3 | 6.36 | 187.3 | 4.16 | 3.39 | 4.60 | 0.40 | 0.160 | 2.51 | |||
| M4 | 8.09 | 168.5 | 3.77 | 3.15 | 4.15 | 0.36 | 0.142 | 2.53 | |||
| M5 | 6.99 | 152.5 | 3.55 | 3.04 | 3.55 | 0.32 | 0.149 | 2.18 | |||
| mean | 6.32 | 181.4 | 4.10 | 3.34 | 4.33 | 0.39 | 0.147 | 2.68 | |||
| std | 0.65 | 12.3 | 0.28 | 0.13 | 0.29 | 0.03 | 0.015 | 0.25 |