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. 2016 Sep 10;6(12):2068–2083. doi: 10.7150/thno.15007

Figure 11.

Figure 11

AZIN1 and JNK1 are downregulated by miR-433 antagomir in vivo. A-B, downregulated AZIN1 and JNK1 in ventricular samples from 21 day post-myocardial infarction (MI) mice, rodent model of doxorubicin (Dox)-induced cardiomyopathy, and human dilated cardiomyopathy (DCM). For Western blot, n=3. For qRT-PCR, n=3 for mice and n=4 for patients; C, Upregulated AZIN1 and JNK1, accompanied by an inactivation of ERK, p38, and Smad3 phosphorylation in MI hearts with miR-433 inhibition (n=4). *, P<0.05, **, P<0.01, ***, P<0.001 versus respective controls.