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. 2016 Sep 10;6(12):2068–2083. doi: 10.7150/thno.15007

Figure 5.

Figure 5

miR-433 promotes cardiac fibroblasts proliferation and their differentiation into myofibroblasts in vitro.A, increased miR-433 in cardiac fibroblasts treated with miR-433 agomir (n=6); B, enhanced cardiac fibroblasts proliferation and their differentiation into myofibroblasts (n=4); C-D, upregulated fibrosis-related genes in cardiac fibroblasts with miR-433 overexpression in the absence of TGF-β stimulation, as evidenced by EdU/α-SMA staining (n=4), qRT-PCR (n=6), and Western blot analysis (n=4); E-F, upregulated fibrosis-related genes in cardiac fibroblasts with miR-433 overexpression in the absence of Angiotensin II stimulation. Scale bar: 50 μm. *, P<0.05, **, P<0.01, ***, P<0.001 versus respective controls.