Table 7. Timing of analysis performed on F1, F2, and F3 offspring exposed to vehicle or caffeine in utero from E10.5–13.5.

Dam	F1 Offspring		F2 Offspring		F3 Offspring
Treatment/Timing	Analysis		Analysis		Analysis
	22 Weeks	52 Weeks	22 Weeks	52 Weeks	22 Weeks	52 Weeks
Vehicle/E10.5–13.5 Caffeine/E10.5–13.5	1) Echos	1) Echos 2) Gene Expression 3) Histology	1) Echos	1) Echos 2) Gene Expression 3) Histology	1) Echos	1) Echos 2) Gene Expression 3) Histology