Table 2. List of hub genes of differential networks detected by TDJGL from the PI3K/AKT/mTOR pathway.

Genes	Degree	GEARcisplatin	GEARdrug	CGC
CCNE2	7|6|7		×
AKT1	5|5|5	×	×	×
FGFR1	5|5|5			×
MYC	5|4|5	×	×	×
TSC2	4|5|5			×
BCL2L1	5|3|5	×	×
INSR	4|4|4
KIT	4|4|4		×	×
PPP2R2B	4|4|4		×
CCND2	4|4|3		×	×
LAMB3	3|4|4
CDKN1A	4|3|3	×	×
GNG12	3|3|4
HGF	3|4|3		×
CASP9	3|3|3	×	×
CCNE1	3|3|3			×
EIF4B	3|3|3
MTCP1	3|3|3			×

If a gene is associated with resistance to cisplatin (GEAR_cisplatin) and resistance to drug (GEAR_drug) according to the database of Genomic Elements Associated with drug Resistance, and causally implicated in cancer (CGC) according to the Cancer Gene Census database, there is an × in the corresponding entry. a|b|c^§ denotes the degree of genes in differential networks constructed from the G450, U133 and HuEx platforms, respectively.