Table 1. Genes within the autophagy pathway differentially expressed following C. concisus UNSW3 or BAA-1457 infection of intestinal epithelial cells.
| Strain | Gene | Gene Description | Fold Change | Fold Regulation | P-value |
|---|---|---|---|---|---|
| UNSW3 | ATG4A | ATG4 autophagy related 4 homolog A (S. cerevisiae) | 0.64 | −1.57 | 0.040 |
| HDAC1 | Histone deacetylase 1 | 0.66 | −1.51 | 0.035 | |
| HSPA8 | Heat shock 70 kDa protein 8 | 0.45 | −2.21 | 0.020 | |
| MAPK14 | Mitogen-activated protein kinase 14 | 0.60 | −1.67 | 0.0037 | |
| PIK3C3 | Phosphoinositide-3-kinase, class 3 | 0.65 | −1.54 | 0.054 | |
| UVRAG | UV radiation resistance associated gene | 0.73 | −1.36 | 0.077 | |
| BAA-1457 | ATG4A | ATG4 autophagy related 4 homolog A (S. cerevisiae) | 0.47 | −2.12 | 0.0048 |
| EIF4G1 | Eukaryotic translation initiation factor 4 gamma, 1 | 0.37 | −2.70 | 0.021 | |
| MAP1LC3B | Microtubule-associated protein 1 light chain 3 beta | 2.63 | 2.63 | 0.0052 | |
| MTOR | Mechanistic target of rapamycin (serine/threonine kinase) | 0.52 | −1.94 | 0.0021 |
Expression was determined using an autophagy-specific qPCR array.
Fold change values < 1, fold regulation refers to the negative inverse of the fold change. When fold change is ≥1, fold regulation = fold change.