Table 2. Regulation of important transcripts associated with pattern recognition receptor signaling pathways upon infection with Campylobacter concisus BAA-1457.
| Type | ENSEMBL ID | Gene | Fold regulation | P-value | Adjusted P-value |
|---|---|---|---|---|---|
| ALR | ENSG00000163565 | IFI16 | 1.23 | 0.015 | 0.036 |
| CLR | ENSG00000069493 | CLEC2D | 1.27 | 0.0011 | 0.0038 |
| ENSG00000198178 | CLEC4C | 1.45 | 1.08E-13 | 2.09E-12 | |
| ENSG00000152672 | CLEC4F | 1.32 | 0.017 | 0.040 | |
| NLR | ENSG00000022556 | NLRP2 | 1.11 | 0.0022 | 0.0070 |
| ENSG00000167634 | NLRP7 | 1.21 | 5.05E-08 | 4.44E-07 | |
| ENSG00000185792 | NLRP9 | 2.28 | 7.79E-11 | 1.05E-09 | |
| SLR | ENSG00000161011 | SQSTM1 | 1.17 | 8.24E-06 | 4.73E-05 |
| ENSG00000188554 | NBR1 | 1.20 | 1.56E-07 | 1.26E-06 | |
| ENSG00000123240 | OPTN | 1.18 | 9.07E-06 | 5.16E-05 | |
| TLR | ENSG00000164342 | TLR3 | 1.55 | 2.53E-07 | 1.97E-06 |
| ENSG00000196664 | TLR7 | 0.72 | 0.00033 | 0.0013 | |
| Caspases | ENSG00000106144 | CASP2 | 0.89 | 0.0055 | 0.015 |
| ENSG00000164305 | CASP3 | 0.77 | 1.29E-11 | 1.90E-10 | |
| ENSG00000196954 | CASP4 | 1.16 | 0.00026 | 0.0011 | |
| ENSG00000132906 | CASP9 | 1.29 | 7.47E-07 | 5.28E-06 | |
| Chemokines | ENSG00000151882 | CCL28 | 2.03 | 8.02E-44 | 1.17E-41 |
| ENSG00000107562 | CXCL12 | 0.84 | 2.48E-06 | 1.59E-05 | |
| ENSG00000145824 | CXCL14 | 0.69 | 1.02E-17 | 3.00E-16 | |
| ENSG00000161921 | CXCL16 | 1.42 | 1.86E-09 | 2.06E-08 | |
| Cytokines | ENSG00000136244 | IL6 | 1.20 | 0.010 | 0.026 |
| ENSG00000145839 | IL9 | 0.76 | 0.0011 | 0.0038 | |
| ENSG00000150782 | IL18 | 1.40 | 5.10E-09 | 5.22E-08 | |
| ENSG00000157368 | IL34 | 1.41 | 0.017 | 0.041 | |
| IRF | ENSG00000125347 | IRF1 | 1.16 | 0.00013 | 0.00056 |
| ENSG00000168310 | IRF2 | 0.83 | 0.0073 | 0.020 | |
| ENSG00000126456 | IRF3 | 0.90 | 0.0077 | 0.021 | |
| ENSG00000117595 | IRF6 | 1.30 | 6.88E-13 | 1.20E-11 |
Expression was determined using RNA-seq technology. Results obtained from the EdgeR tool were analysed. A complete list of regulated genes involved in these pathways including cytokine receptors and adaptor molecules can be found in Supplementary Data 1.
ALR: AIM2-like receptors; CLR: C-type lectin receptor; NLR: NOD-like receptor; SLR: sequestosome 1/p62-like receptors; TLR: Toll-like receptor; IRF: Interferon regulatory factors.