Table 3. Regulation of important transcripts associated with pattern recognition receptor signaling pathways upon exposure to C. concisus Zonula occludens toxin.
| Type | ENSEMBL ID | Gene | Fold regulation | P-value | Adjusted P-value |
|---|---|---|---|---|---|
| NLR | ENSG00000022556 | NLRP2 | 1.22 | 0.00046 | 0.012 |
| ENSG00000179873 | NLRP11 | 0.55 | 0.00059 | 0.014 | |
| TLR | ENSG00000164342 | TLR3 | 1.35 | 0.0028 | 0.046 |
| Caspases | ENSG00000165806 | CASP7 | 1.30 | 2.46E-05 | 0.0011 |
| Chemokines | ENSG00000161921 | CXCL16 | 1.39 | 8.79E-05 | 0.0030 |
| Cytokines | ENSG00000136244 | IL6 | 1.68 | 6.03E-06 | 0.00033 |
| ENSG00000169429 | IL8 | 1.44 | 0.00011 | 0.0037 | |
| IRF | ENSG00000125347 | IRF1 | 1.20 | 0.0022 | 0.039 |
Expression was determined using RNA-seq technology. Results obtained from the EdgeR tool were analysed. A complete list of regulated genes involved in these pathways including cytokine receptors and adaptor molecules can be found in Supplementary Data 1.
NLR: NOD-like receptor; TLR: Toll-like receptor; IRF: Interferon regulatory factors.