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. 2016 Sep 28;6:33972. doi: 10.1038/srep33972

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Copyright © 2016, The Author(s)

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(a,b) Reporter gene assays using consensus (2ConA) and a putative Trichoplax p53 response element (TXRe540) show no transcriptional activation for Tap53 and Tap53Δ in H1299 cells. p53 is however capable of transactivation using TXRe540 response element. (c) Co-expression of TaMdm2 results in reduced p53 function in reporter gene assay using 2ConA promoter. TaMdm2 expression was also reduced (20-fold reduction of TaMdm2 expression plasmid co-transfected) to give a more comparable yield with MDM2 as shown in Western blot below. Data shows average of 2 independent experiments ± SD. See Supplementary Information for uncropped blots.