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. 2016 Sep 28;6:34196. doi: 10.1038/srep34196

Figure 2. CS synapses in the ventral spinal cord were eliminated upon increasing synaptic 2B.

Figure 2

(A) Reduction of CS synaptic activity in the ventral side after the critical period in 2a−/− mice. Spatial distribution of CS synapses determined using optical CS-EPSPs in WT, proBDNF-treated or 2a−/− mice at 11–13 or 14–16 DIV. Scale bar = 250 μm. (B) Ventrodorsal ratios of optical CS-EPSPs in the indicated culture pairs from 11–13 DIV (0.40 ± 0.03 in WT mice, n = 12, Ns = 12, Nm = 6; 0.42 ± 0.03 in 2a−/− mice, n = 6, Ns = 6, Nm = 6) or from 14–16 DIV (0.46 ± 0.02 in WT mice, n = 17, Ns = 17, Nm = 8; 0.39 ± 0.02 in proBDNF-treated mice, n = 4, Ns = 4, Nm = 4; 0.31 ± 0.03 in 2a−/− mice, n = 7, Ns = 7, Nm = 6).