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. 2016 Sep 28;6:34164. doi: 10.1038/srep34164

Figure 1. SVV infection results in inflammation.

Figure 1

(a) SVV viral loads in lung biopsies, bronchial alveolar lavage (BAL) and blood (WB) were measured by quantitative PCR using primers and probes specific for SVV ORF21 (BAL: n = 14 (0 days post infection, DPI), n = 11 (3 DPI), n = 8 (7 DPI), n = 5 (10 DPI), n = 3 (14 DPI); Lung: n = 3 (0 DPI), n = 3 (3 DPI), n = 3 (7 DPI), n = 2 (10 DPI), n = 3 (14 DPI); WB: n = 14 (0 DPI), n = 11 (3 DPI), n = 8 (7 DPI), n = 5 (10 DPI), n = 3 (14 DPI)) (#p < 0.05 for left lung; $p < 0.05 for BAL; &p < 0.05 for WB; *p < 0.05 for right lung relative to day 0). (b) SVV infection results in focal hemorrhage during peak viral replication that largely resolved 14 DPI. (c) H&E staining shows immune infiltrates and lung consolidation during peak viral replication. (d) VZVgB staining showing high levels of viral antigen 7 DPI that were decreased 14 DPI.