Table 11. Values of the Key Properties Correlated with Higher Affinities at the Four Identified Positions^a.

		PAK1 (mean pKi = 5.12)		TYRO3 (mean pKi = 5.69)		FLT1 (mean pKi = 6.47)
position	desirable property (unit)	amino acid	value	amino acid	value	amino acid	value
13	large size (Da)	Asn329	132	Lys572	146	Asn893	132
13	electrophilicity (KD score)	Asn329	–3.5	Lys572	–3.9	Asn893	–3.5
23	large size (Da)	Gly349	75	His598	155	Tyr914	181
31	small size (Da)	Lys391	146	Ala647	89	Ala1024	89
31	hydrophobicity (KD score)	Lys391	–3.9	Ala647	1.8	Ala1024	1.8
35	hydrophobicity (KD score)	Thr406	–0.7	Ala662	1.8	Cys1039	2.5

^aThe KD score corresponds to the Kyte and Doolitle hydrophobicity⁹⁶.