Table 12. List, Amino Acid Identities and Locations of the Four Positions Identified by the PCM Models and of the C- and R-Spine Amino Acids in Their Vicinity.

	amino acid	location
position 13	Asn329	N lobe, ß4 strand
R-Spine	Tyr330	N lobe, ß4 strand
position 23	Gly349	N lobe ß4 strand to C lobe D-helix loop
C-Spine	Leu352	C lobe, D-helix
R-Spine	His387	C lobe, catalytic loop
position 31	Lys391	C lobe, catalytic loop
C-Spine	Ile395	C lobe, ß7 strand
C-Spine	Leu396	C lobe, ß7 strand
C-Spine	Leu397	C lobe, ß7 strand
position 35	Thr406	C lobe, activation loop
R-Spine	Phe408	C lobe, activation loop