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. 2016 Sep 28;6:34171. doi: 10.1038/srep34171

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Representative CEST (a,c,e,g) and RD (b,d,f,h) profiles. The experimental CEST data at rf fields of 13.6 and 27.2 Hz are indicated by “o” and “●”, respectively. The experimental RD data at 800 and 500 MHz are indicated by “o” and “●”, respectively. The solid lines are best fits obtained with model I (a–d, g,h) and model IV (e,f). The locations (or chemical shifts) of states N, I1, I2, and I3 in the CEST profiles are indicated by arrows.