Table 1.

Comparison of different methods on the S2648 dataset

Method	All mutations			Common mutations			P-valued
	na	γb	σc	na	γb	σc
I-Mutent3.0	2636	0.60	1.19	2484	0.60	1.19	7.2E-28
INPS	2648	0.56	1.26	2484	0.56	1.26	5.3E-46
mCSM	2643	0.69	1.07	2484	0.70	1.07	1.4E-18
PoPMuSiC	2647	0.61	1.17	2484	0.61	1.17	1.6E-25
STRUM	2647	0.77	0.94	2484	0.78	0.92

^an, number of mutations obtained from the programs.

^aγ, PCC between predicted and experiment $\Delta \Delta G.$

^aσ, RMSE of $\Delta \Delta G$ prediction in Kcal/mol.

^aP-value, P-value in Wilcoxon test between the RMSE of STRUM and that by the control methods on the common mutations.