Table 2.

Summary of protein-level and position-level cross validation on the S2648 dataset

Method	Protein-levela		Position-levelb
	γd	σe	γd	σe
INPSc	0.52	1.26	0.54	1.28
mCSMc	0.51	1.26	0.54	1.23
STRUM	0.54	1.25	0.64	1.14

^aProtein-level, mutation samples are divided based on their protein origin.

^aPosition-level, mutation samples are divided based on their positions.

^aINPS, mCSM, data taken from authors’ publications.

^aγ, PCC between predicted and experimental $\mathrm{\Delta }\mathrm{\Delta }G.$

^aσ, RMSE of $\mathrm{\Delta }\mathrm{\Delta }\mathrm{G}$ prediction in Kcal/mol.