Table 1. Characteristics of enrolled cases .

Patients’ characteristics
Age	10-324 (181.9 ± 82.5) months
Gender	15 (46.9%) girls and 17 ( 53.1%) boys
Modality of dialysis	21 (65.6%) HD and 12 (34.4%) CAPD subjects
Duration from onset of dialysis	1-153 (38.9 ± 38.5) months
Etiologies of CKD	Vesicoureteral reflux (VUR); 11 (34.4%) Neurogenic bladder; 7 (21.9%) Unknown; 7 (21.9%) Nephrotic syndrome; 4 (18.8%) Lupus nephropathy; 1 (3.1%) Familial juvenile nephronophtisis; 1 (3.1%) Autosomal recessive polycystic diseases; 1 (3.1%)
Dose of folate supplement before intervention	0.125-6 (1.5 ± 1.9) mg/daya, median 0.5 mg/day
Dose of vitamin B12 supplement before intervention	0-6 (4.2 ± 2.3) µg/dayb, median 6 µg/day
History of renal transplantation	2 (6.3%) cases had received kidney transplantation in the past
Urine output	12 (37.5%) subjects were anuric
Hours of dialysis per week in HD cases	7-12 (10.2 ± 1.2)
Number of dialysis cycle per day in CAPD patients	3-6 (5±0.9)
Volume in each cycle (cc/kg) in CAPD patients	30-50 (37.7±6.4)
Duration of each cycle (hour) in CAPD patients	1-5 (3±0.96)

Abbreviations: HD, Hemodialysis; CAPD, continuous ambulatory peritoneal dialysis; CKD, Chronic kidney diseases.

^aTwenty-one cases (65.6%) supplemented by 0.5 and 6 (18.7%) cases ≥5 mg/day.

^bTwenty-four cases ( 75% ) supplemented by 6 µg/day vitamin B12 and 6 cases (18.7%) did not receive any vitamin B12 supplement.