FIG 3 .

Clinical and environmental isolates present a spectrum of virulence in the triamcinolone model of IPA but not in a chemotherapeutic model. (A and B) Data are separated into two distinct graphs for easy viewing. Triamcinolone-treated CD-1 mice inoculated with 2 × 10⁶ conidia of 02-10 (n = 12), 47-9 (n = 11), 02-30 (n = 12), 47-10 (n = 16), 47-4 (n = 16), 47-60 (n = 12), 47-7 (n = 12), 02-46 (n = 13), W72310 (n = 16), or 47-57 (n = 16) reveal a range of virulence levels across the isolates. (C) Clinical isolates (n = 16 per strain) inoculated in triamcinolone-treated CD-1 mice at 2 × 10⁶ conidia reveal reduced heterogeneity in virulence (curves not significantly different by log rank test; P = 0.2296). (D) Survival of mice treated with both cyclophosphamide and triamcinolone (chemotherapeutic model) were inoculated with 2 × 10⁶ conidia of 47-4, 02-10, or EVOL20 (n = 12 per strain). In this model, all three strains produce curves that are indistinguishable from one another (log rank, P = 0.1851 for 47-4 and 02-10).