FIG 4 .

Higher ratio of hypoxia-to-normoxia biomass correlates with increased virulence in the triamcinolone model of IPA. (A) Ratio of liquid culture biomass in hypoxia (0.2% O₂) to normoxia (~21% O₂) for environmental and clinical isolates. (B to D) Spearman rank order correlations calculated from H/N ratio and median survival (n = 16; r = −0.7867; P = 0.0003) for all strains (B) (clinical isolates [diamonds], lab-utilized “WT” strains [squares], and environmental isolates [circles]) and separated by environmental (n = 10; r = −0.7031; P = 0.0268) (C) and clinical (n = 6; r = −0.9429; P = 0.0390) (D) isolates. (E and F) Spearman rank order correlations and median survival for all 16 strains of hypoxia-only biomass (r = −0.6788; P = 0.0038) (E) and normoxia-only biomass (r = 0.5199; P = 0.0390) (F).