Table 2.
Main results balance study.
| s[Na] < 143 mmol/L | s[Na] ≥ 143 mmol/L | p value | |
|---|---|---|---|
| Length of stay, days | 4 [3–5] | 7 [4–15] | <0.001 |
| SOFA score after 24 hours | 6 [4–7] | 8 [5–10] | 0.02 |
| SOFA score after 48 hours | 5 [3–6] | 7 [4–10] | <0.001 |
| Fluid intake after 24 hours, L | 4.4 [3.7–5.6] | 3.8 [2.9–6.3] | 0.54 |
| Fluid intake after 48 hours, L | 7.5 [6–9.2] | 6.9 [5.3–9.2] | 0.59 |
| Fluid balance after 24 hours, L1 | 2 [1–2.8] | 1.6 [0.6–3.7] | 0.78 |
| Fluid balance after 48 hours, L1 | 2.3 [1–3.7] | 2.5 [0.8–4.2] | 0.77 |
| Sodium intake after 24 hours, grams | 9.6 [6.9–11.8] | 9.7 [5.9–15.8] | 0.70 |
| Sodium intake after 48 hours, grams | 12.5 [9.3–17.5] | 15.8 [9–21.9] | 0.13 |
| Serum creatinine after 24 hours, µmol/L | 87 [66–130] | 81 [65–110] | 0.40 |
| Serum creatinine after 48 hours, µmol/L | 79 [60–116] | 77 [61–121] | 0.91 |
| Serum urea after 24 hours, mmol/L | 8 [6–10] | 7 [5–11] | 0.47 |
| Serum urea after 48 hours, mmol/L | 8 [6–12] | 9 [5–13] | 0.71 |
| Number of patients on furosemide after 24 h | 5 | 4 | 1 |
| Total dose furosemide after 24 h, mg | 20 [20–60] | 60 [25–400] | 0.29 |
| Number of patients on furosemide after 48 h | 18 | 15 | 0.83 |
| Total dose furosemide after 48 h, mg | 30 [20–60] | 40 [20–60] | 0.19 |
sNa: serum sodium concentration; SOFA: Sequential Organ Failure Assessment. 1Fluid balances are as extracted from the patient data management system, minus 500 mL of expected insensible loss per day of admission. Data are presented as median [IQR] or as absolute numbers (%).