Table 5.
The enriched Gene Ontology and pathway terms of lncRNAs that are differentially expressed in the both mild and severe pneumonia.
| LncRNA | Category | ID | Term | FDR | Gene count | Target genes |
|---|---|---|---|---|---|---|
| AJ006995.3 | BP | GO: 1901137 | Carbohydrate derivative biosynthetic process | 0.004964 | 5 | NME6, SEC23A, ADSL, POFUT1, ST6GALNAC5 |
| GO: 0006486 | Protein glycosylation | 0.016382 | 3 | SEC23A, POFUT1, ST6GALNAC5 | ||
| GO: 0043413 | Macromolecule glycosylation | 0.016382 | 3 | SEC23A, POFUT1, ST6GALNAC5 | ||
| GO: 0070085 | Glycosylation | 0.016382 | 3 | SEC23A, POFUT1, ST6GALNAC5 | ||
| GO: 1901135 | Carbohydrate derivative metabolic process | 0.019142 | 6 | NME6, SEC23A, ADSL, POFUT1, ARHGEF28, ST6GALNAC5 | ||
| CTD-2210P24.6 | MF | GO: 1901363 | Heterocyclic compound binding | 0.017896 | 16 | FOXP4, POU2F3, MAGI3, DDX25, HOXA13, NLRP9, MTA3, KIAA1586, BMPR1B, SRPK1, UBE2G2, UBP1, METTL16, CGGBP1, USP6, POLR1C |
| GO: 0097159 | Organic cyclic compound binding | 0.017896 | 16 | FOXP4, POU2F3, MAGI3, DDX25, HOXA13, NLRP9, MTA3, KIAA1586, BMPR1B, SRPK1, UBE2G2, UBP1, METTL16, CGGBP1, USP6, POLR1C | ||
| GO: 0005488 | Binding | 0.017896 | 24 | FOXP4, ADRA1B, NLGN4Y, POU2F3, MAGI3, DDX25, HOXA13, NLRP9, KRT8, RUFY2, MTA3, KIAA1586, BMPR1B, SRPK1, UBE2G2, UBP1, METTL16, FRAS1, CGGBP1, LGR5, EED, USP6, INTS4, POLR1C | ||
| GO: 0003700 | Sequence-specific DNA binding transcription factor activity | 0.019057 | 6 | FOXP4, POU2F3, HOXA13, MTA3, UBP1, CGGBP1 | ||
| GO: 0001071 | Nucleic acid binding transcription factor activity | 0.019057 | 6 | FOXP4, POU2F3, HOXA13, MTA3, UBP1, CGGBP1 | ||
| CTD-2300H10.2 | BP | GO: 0046639 | Negative regulation of alpha-beta T cell differentiation | 7.61E-05 | 3 | RC3H1, IHH, IL4 |
| GO: 0046636 | Negative regulation of alpha-beta T cell activation | 0.000187 | 3 | RC3H1, IHH, IL4 | ||
| GO: 0045581 | Negative regulation of T cell differentiation | 0.000269 | 3 | RC3H1, IHH, IL4 | ||
| GO: 0045620 | Negative regulation of lymphocyte differentiation | 0.000617 | 3 | RC3H1, IHH, IL4 | ||
| GO: 0046637 | Regulation of alpha-beta T cell differentiation | 0.00103 | 3 | RC3H1, IHH, IL4 | ||
| CC | GO: 0032587 | Ruffle membrane | 0.015463 | 3 | EPS8, PLA2G4F, PDE9A | |
| GO: 0031256 | Leading edge membrane | 0.033811 | 3 | EPS8, PLA2G4F, PDE9A | ||
| GO: 0001726 | Ruffle | 0.039361 | 3 | EPS8, PLA2G4F, PDE9A | ||
| MF | GO: 0052689 | Carboxylic ester hydrolase activity | 0.000439 | 4 | ACOT2, ESD, ACOT9, PLA2G4F | |
| GO: 0016790 | Thiolester hydrolase activity | 0.001389 | 3 | ACOT2, ESD, ACOT9 | ||
| GO: 0016788 | Hydrolase activity, acting on ester bonds | 0.027305 | 5 | ACOT2, ESD, ACOT9, PLA2G4F PDE9A | ||
| RP11-96C23.9 | MF | GO: 0016773 | Phosphotransferase activity, alcohol group as acceptor | 0.020183 | 6 | SRPK3, NMRK2, PDK2, CNTLN, RELN, PIP5K1B |
| GO: 0016301 | Kinase activity | 0.020183 | 6 | SRPK3, NMRK2, PDK2, CNTLN, RELN, PIP5K1B | ||
| GO: 0016772 | Transferase activity, transferring phosphorus-containing groups | 0.028775 | 6 | SRPK3, NMRK2, PDK2, CNTLN, RELN, PIP5K1B | ||
| GO: 0016740 | Transferase activity | 0.028775 | 9 | MBOAT2, PPIL2, SRPK3, NMRK2, PDK2, CNTLN, RELN, VCPKMT, PIP5K1B | ||
| RP11-248E9.5 | BP | GO: 0008150 | Biological process | 0.002259 | 101 | ZNF717, ARL4C, ZNF460, GPR75, UGT2A1, CHEK1, ERI2, CPE, DHRS13, ZNF418, TTC9B, IL23R, ADRA2B, SNRNP48, ADSL, DPH2, TIGIT, CERS3, EPS8, FANCF, OR4D11, LHFPL5, MYO16, CDY1B, PRPF40B, LRIG1, STEAP2, MSTN, OR2V1, ANG, CLEC9A, TMPRSS12, KCNRG, GPR22, FRYL, SCAI, GPX5, VN1R2, OR2AG2, TRIML1, IFNA14, ACTBL2, QRFP, OR6B2, OR4K17, OR13C6P, OR51A4, VN1R17P, CEP83, TCEB3B, SCARA3, LARP7, ASB1, PLCB4, SPIN2A, PCDH18, PPP2R3A, CHST12, TNFRSF19, FAM46A, KIF16B, EXOC1, PCDHA7, PRDM11, TAS2R38, RIMKLB, ZNF687, BAK1, HRH4, BCL2, RYR2, BLOC1S5, ARHGEF28, SH3GL3, SMYD3, RFX7, SNAPC3, SOX3, TFAM, THY1, KRTAP4–8, ZNF140, CEP97, OR4A16, OR12D3, FCRL4, C19orf12, HPS3, DUSP11, SORBS2, PPFIBP2, RTCA, NRP2, TGIF2LX, ANGPTL1, HTR3B, MMP20, RIN1, PCDHA9, TECPR2, JOSD1 |
| GO: 0007186 | G-protein coupled receptor signaling pathway | 0.002613 | 20 | GPR75, CPE, ADRA2B, OR4D11, OR2V1, GPR22, VN1R2, OR2AG2, QRFP, OR6B2, OR4K17, OR13C6P, OR51A4, VN1R17P, TAS2R38, HRH4, RYR2, OR4A16, OR12D3, HTR3B | ||
| GO: 0009593 | Detection of chemical stimulus | 0.017347 | 11 | UGT2A1, OR4D11, OR2V1, OR2AG2, OR6B2, OR4K17, OR51A4, TAS2R38, RYR2, OR4A16, OR12D3 | ||
| GO: 0007606 | Sensory perception of chemical stimulus | 0.017347 | 11 | UGT2A1, OR4D11, OR2V1, OR2AG2, OR6B2, OR4K17, OR13C6P, OR51A4, TAS2R38, OR4A16, OR12D3 | ||
| GO: 0007608 | Sensory perception of smell | 0.021759 | 10 | UGT2A1, OR4D11, OR2V1, OR2AG2, OR6B2, OR4K17, OR13C6P, OR51A4, OR4A16, OR12D3 | ||
| RP11-248E9.5 | MF | GO: 0003674 | molecular_function | 2.96E-05 | 99 | ZNF717, ARL4C, ZNF460, GPR75, UGT2A1, CHEK1, CHGB, ERI2, C1orf131, SLX4IP, CPE, DHRS13, ZNF418, TTC9B, IL23R, ADRA2B, SNRNP48, ADSL, TIGIT, CERS3, EPS8, FANCF, OR4D11, MYO16, CDY1B, STEAP2, MSTN, OR2V1, ANG, CLEC9A, TMPRSS12, KCNRG, GPR22, SCAI, GPX5, VN1R2, OR2AG2, TRIML1, IFNA14, ACTBL2, QRFP, OR6B2, OR4K17, OR13C6P, OR51A4, VN1R17P, CEP83, TCEB3B, SCARA3, LARP7, ASB1, PLCB4, SPIN2A, PCDH18, PPP2R3A, CHST12, TNFRSF19, FAM46A, KIF16B, EXOC1, PCDHA7, PRDM11, TAS2R38, RIMKLB, ZNF687, BAK1, HRH4, BCL2, RYR2, BLOC1S5, ANKEF1, ARHGEF28, CEP170P1, SH3GL3, SMYD3, RFX7, SNAPC3, SOX3, TFAM, THY1, ZNF140, CEP97, OR4A16, OR12D3, FCRL4, EFCAB7, DUSP11, SORBS2, PPFIBP2, RTCA, NRP2, TGIF2LX, ANGPTL1, HTR3B, MMP20, RIN1, PCDHA9, TECPR2, JOSD1 |
| GO: 0004930 | G-protein coupled receptor activity | 0.000121 | 17 | GPR75, ADRA2B, OR4D11, OR2V1, GPR22, VN1R2, OR2AG2, OR6B2, OR4K17, OR13C6P, OR51A4, VN1R17P, TAS2R38, HRH4, OR4A16, OR12D3, HTR3B | ||
| GO: 0004888 | transmembrane signaling receptor activity | 0.000206 | 20 | GPR75, IL23R, ADRA2B, OR4D11, OR2V1, GPR22, VN1R2, OR2AG2, OR6B2, OR4K17, OR13C6P, OR51A4, VN1R17P, TNFRSF19, TAS2R38, HRH4, OR4A16, OR12D3, NRP2, HTR3B | ||
| GO: 0038023 | signaling receptor activity | 0.000484 | 20 | GPR75, IL23R, ADRA2B, OR4D11, OR2V1, GPR22, VN1R2, OR2AG2, OR6B2, OR4K17, OR13C6P, OR51A4, VN1R17P, TNFRSF19, TAS2R38, HRH4, OR4A16, OR12D3, NRP2, HTR3B | ||
| GO: 0004872 | receptor activity | 0.001039 | 21 | GPR75, IL23R, ADRA2B, OR4D11, OR2V1, GPR22, VN1R2, OR2AG2, OR6B2, OR4K17, OR13C6P, OR51A4, VN1R17P, SCARA3, TNFRSF19, TAS2R38, HRH4, OR4A16, OR12D3, NRP2, HTR3B | ||
| KEGG | hsa04740 | Olfactory transduction | 0.001791994 | 7 | OR12D3, OR2AG2, OR4A16, OR4D11, OR4K17, OR51A4, OR6B2 | |
| RP11-456D7.1 | MF | GO: 0003674 | molecular_function | 0.007716221 | 61 | TANK, USP17L12, DSCR4, SCML2, SCGN, KHDRBS3, ZBTB6, OSBPL7, C1QTNF3, RBP7, CLCN4, GJD3, OR2T34, OR2T4, COX5B, CCBE1, UPP2, EPHA2, TXLNA, FOXL1, IQSEC2, TNFRSF13B, KIF4A, ATXN10, TRAF3IP1, GMFB, ANXA4, ZACN, LDHC, ATP2B3, OCRL, TAS2R8, PDK2, ACP5, PPP1R3D, PRIM2, PRKAA1, POLR3B, WWC3, PCDHGA7, TMX4, AARS2, NTN4, OPN1LW, RGS13, CCL21, PGA3, ZCCHC18, NMNAT1, SMARCD1, TACR1, CA6, OR51B2, COLQ, PPFIA4, ENDOU, BUB3, ZMYM3, GPR52, FEZ2, IKBKE |
LncRNA – long non-coding RNA; GO – Gene Ontology; MF – molecular function; CC – cellular component; BP – biological process; FDR – false discovery rate.