Table 1. IC50s of FQs against DNA gyrases of WT and mutant M. leprae.
Drug | IC50 (μg/mL) | |||
---|---|---|---|---|
WT | Gly89Cys | Ala91Val | Asp95Gly | |
DC-159a | 0.4 ± 0.0 | 2.3 ± 0.3 | 0.7 ± 0.1 | 2.8 ± 0.1 |
Sitafloxacin | 0.2 ± 0.0 | 1.9 ± 0.1 | 0.4 ± 0.1 | 1.9 ± 0.1 |
Moxifloxacin | 1.1 ± 0.0 | 22.6 ± 2.9 | 2.1 ± 0.1 | 12.2 ± 1.3 |