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. 2016 Sep 28;10(9):e0005013. doi: 10.1371/journal.pntd.0005013

Table 1. IC50s of FQs against DNA gyrases of WT and mutant M. leprae.

Drug IC50 (μg/mL)
WT Gly89Cys Ala91Val Asp95Gly
DC-159a 0.4 ± 0.0 2.3 ± 0.3 0.7 ± 0.1 2.8 ± 0.1
Sitafloxacin 0.2 ± 0.0 1.9 ± 0.1 0.4 ± 0.1 1.9 ± 0.1
Moxifloxacin 1.1 ± 0.0 22.6 ± 2.9 2.1 ± 0.1 12.2 ± 1.3