Table 3.

Multivariate Analysis of Associations Between Grade, Comedonecrosis, Multicentricity with Mammographic Features and ER Status in 1657 Patients with Pure DCIS

Feature		Grade 3 (N=854)		Comedonecrosis (N=855)		Multicentricity (N=663)
		Odds Ratio (95% CI)	p value	Odds Ratio (95% CI)	p value	Odds Ratio (95% CI)	p value
Breast density	Fatty/scattered	1 (−)	-	1 (−)	-	1 (−)	-
	Heterogeneously dense	1.2 (0.8–1.6)	0.37	1.1 (0.8–1.5)	0.57	1.1 (0.6–1.8)	0.80
	Extremely dense	1.0 (0.5–1.9)	0.98	0.9 (0.5–1.6)	0.62	3.1 (1.3–7.0)	<0.01
Microcalcification morphology	Punctate/amorphous	1 (−)	-	1 (−)	-	1 (−)	-
	Coarse heterogeneous/fine pleomorphic	2.3 (1.5–3.3)	<0.0001	1.4 (1.0–2.0)	0.08	1.4 (0.8–2.6)	0.25
	Fine linear (branching)	3.4 (1.9–6.1)	<0.0001	1.7 (1.0– 2.9)	<0.05	0.7 (0.3–1.7)	0.44
Microcalcification distribution	Clustered/grouped	1 (−)	-	1 (−)	-	1 (−)	-
	Linear/segmental	1.3 (0.8–1.9)	0.27	1.6 (1.1–2.4)	<0.02	0.9 (0.5–1.8)	0.83
	Regional/diffuse	1.0 (0.6–1.7)	0.97	1.4 (0.8–2.2)	0.21	1.6 (0.8–3.1)	0.15
Mammographic size		1.1 (1.0–1.2)	0.02	1.2 (1.1–1.3)	<0.0001	1.4 (1.3–1.5)	<0.0001
ER-negative status		30.8 (12.4–76.6)	<0.0001	3.2 (2.1–4.7)	<0.0001	1.4 (0.8–2.4)	0.21

Note: Multiple logistic regression analysis was implemented using the set of independent variables (breast density, microcalcification morphology, microcalcification distribution, mammographic size, ER-negative status) for each dependent variable (grade 3, comedonecrosis, and multicentricity). P values for the partial odds ratios derive from the two-sided Wald test. For categorical predictors with three factor levels, the partial odds ratio for observing the dependent variable is provided in relation to the reference category indicated by 1 (−). For mammographic size, the partial odds ratio is provided per unit increase in cm.