Closed-loop clinical trial example 1; see Sec. 6.3. Top: CGM (blue dots), [80, 140] mg/dL (green area), [70, 180] mg/dL (yellow area), exercise period (gray area), diurnal target zone (black lines), dinner (Di), breakfast (Br), and lunch (Lu) sizes. Bottom: Closed-loop insulin delivery (red line), open-loop meal-boluses (blue bars), basal rate (dashed green line), diurnal safety constraint (black line).