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. Author manuscript; available in PMC: 2016 Sep 28.
Published in final edited form as: Cell Rep. 2016 Sep 6;16(12):3208–3218. doi: 10.1016/j.celrep.2016.08.079

Figure 1. Viral burden in the eyes, tears, and lacrimal gland of ZIKV-infected animals.

Figure 1

Four-week-old mice were infected with 103 FFU of ZIKV Brazil (Paraiba 2015). Viral burden was measured by qRT-PCR assay. (A) Viral burden in the eyes of WT mice on days 2 and 6 after infection with ZIKV Brazil (Paraiba 2015) or French (H/PF/2013). Mice were treated with 2 mg of an anti-Ifnar1 or control mAb one day prior to infection.(B) Viral burden in the eyes of Ifnar1−/− mice on days 6, 7, and 8 after infection with ZIKV Brazil (Paraiba 2015). (C) Viral burden in the eyes and brain of Ifnar1−/− mice on day 28 after infection with ZIKV Brazil (Paraiba 2015). (D) Viral RNA in tears of mock- and ZIKV-infected Ifnar1−/− mice on day 7 after infection with ZIKV Brazil (Paraiba 2015). (E) Viral RNA in the lacrimal gland of mock- and ZIKV-infected Ifnar1−/− mice on day 7 after infection with ZIKV Brazil (Paraiba 2015). Symbols are derived from individual animals and pooled from 2 or 3 independent experiments. Bars indicate the mean of 5 to 13 mice per group. Dotted lines represent the limit of sensitivity of the assay.