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. 2016 Sep 23;22:1103–1121.

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Copyright © 2016 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

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ZO-1 expression in the RPE of the WT and p27 KO retinas after photoreceptor damage. A: ZO-1 immunolabeling is detected in the apical junctions of the RPE (arrows) and the outer limiting membrane (OLM, arrowheads). In the knockout (KO) retinas, the ZO-1-labeled OLM is disrupted where the RPE protrusions invade into the ONL (asterisks). Note attenuated ZO-1 labeling in the wild-type (WT) RPE after photoreceptor damage. DIC, differential interference contrast; Cont, control; ONL, outer nuclear layer. Scale bar = 20 μm. B: ZO-1 immunolabeling in whole mount RPE preparations, showing the significantly irregular size and shape of mutant RPE cells at day 3 after N-methyl-N-nitrosourea (MNU) treatment. Scale bar = 20 μm.