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. Author manuscript; available in PMC: 2016 Sep 28.
Published in final edited form as: Annu Rev Anal Chem (Palo Alto Calif). 2014;7:129–161. doi: 10.1146/annurev-anchem-071213-020208

Figure 8.

Figure 8

Spectra from Ref. (83) illustrating the dynamic capabilities of the ultraSOFAST 2D experiment. Conformational transitions of a riboswitch are followed by recording real-time 2D 1H-15N HMQC NMR spectra. The spectra shown were recorded at pH = 6.1 and 298 K on a ∼1.7 mM 15N-G-labeled adenine riboswitch ligand-binding domain; the times indicated in each frame correspond to the time point following addition of adenine and Mg2+ to the free RNA solution.