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. Author manuscript; available in PMC: 2016 Dec 15.
Published in final edited form as: Nature. 2016 Jun 15;534(7607):335–340. doi: 10.1038/nature18282

Figure 5. NSun2-deletion imposes distinct translational programmes.

Figure 5

a, b, Percentage of NSun2-methylated cytosines (dark red). c, Un-methylated tRNAs are cleaved and 5’tRNA fragments accumulate. d, Relative frequencies of tRNA fragments in tumours. e, No correlation between changes in protein synthesis and RNA expression in tumours. f, g, Significantly (p<0.05) changed 5’UTR ribosome densities in tumours (f) and human NSun2-/- lines (excluding significant (p<0.05) changes in NSun2+/-) (g) and corresponding CDS. ****p<0.0001 (two-tailed Student’s t-test). h, i, Frequency of ribosomal density values (p-value<0.05 and abs(log2FC)>0) (h) and Gene Ontology (GO) categories in tumours. j, GO categories of significant (p<0.05) changed 5’UTRs in NSun2-/- lines versus +/-. Data: average of 4 replicates per condition in human (g, j) and mouse (a-d) or 3 in (e,f,h,i).