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Different patterns that connect changes in local (top) to global motions (bottom) following the introduction of protein perturbants. In A, both the global energy landscape and the local distance sampling are altered. In B and C, the effects are uncoupled. The distinction between B and C is that (B) represents native SLO-1 while (C) represents SLO-1 variants for which protein have already been altered by mutagenesis.
