Table 3. Results of linear mixed-model analysis.

Variable (nd.f., dd.f)	Hippocampus		Thalamus		Caudate		Putamen		Pallidum		Amygdala		Accumbens
	F	P-value	F	P-value	F	P-value	F	P-value	F	P-value	F	P-value	F	P-value
Diagnosis (1, 82)	16.91	<0.001*	10.22	0.002*	4.48	0.04*	3.04	0.09	3.84	0.05	1.67	0.20	6.10	0.02*
Hemisphere (1, 82)	0.01	0.93	0.19	0.67	0.32	0.58	0.36	0.55	0.31	0.58	0.15	0.70	0.85	0.36
Site (2, 82)	0.97	0.38	1.36	0.26	2.33	0.10	0.44	0.65	0.23	0.79	0.60	0.55	0.05	0.95
Diagnosis×hemisphere (1, 82)	0.32	0.57	0.01	0.94	0.0003	0.99	0.04	0.84	0.59	0.44	0.51	0.48	4.95	0.03*
Diagnosis×site (2, 82)	3.09	0.05	0.12	0.89	1.95	0.15	3.09	0.05	0.52	0.59	4.21	0.02*	1.07	0.35
Diagnosis×site×hemisphere (4, 82)	1.19	0.32	0.57	0.69	2.23	0.07	1.70	0.16	1.89	0.12	0.32	0.87	0.84	0.51
Sex (1, 82)	18.93	<0.001*	0.04	0.84	1.78	0.19	0.62	0.43	0.08	0.78	3.42	0.07	0.00	0.98
Age (1, 82)	0.09	0.76	0.01	0.92	10.03	0.002*	1.97	0.16	0.27	0.60	1.79	0.19	2.22	0.14
Education (1, 82)	4.59	0.04*	1.47	0.23	0.02	0.89	0.02	0.88	0.26	0.61	1.13	0.29	0.05	0.82

Abbreviations: dd.f., denominator degrees of freedom; corrected for multiple comparison; nd.f., nominator degrees of freedom; *, significant findings.