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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: J Appl Toxicol. 2016 Mar 28;36(11):1446–1459. doi: 10.1002/jat.3300

Figure 6.

Figure 6

Arsenic dampens Ca2+ influx into antigen-activated RBL-2H3 cells. Fluo-4/AM was used to measure Ca2+ levels within RBL-2H3 cells which had been sensitized with anti-DNP IgE (0.1μg mL-1) for 1 hr before exposure to ± 0.0002 μg mL-1 DNP-BSA Ag ± 750ppb As, at 30 minutes (A) or 1 hour (B) post-Ag stimulation. Control samples received no As or Ag. Values represent mean (normalized to 0 ppb As) ± SEM of four experiments, with 8-16 replicates per dose per experiment. Statistical significance, as compared to the 0 ppb As sample, was determined by one-way ANOVA followed by Tukey's post test; ***p<0.001