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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: J Appl Toxicol. 2016 Mar 28;36(11):1446–1459. doi: 10.1002/jat.3300

Figure 8.

Figure 8

Arsenic inhibits phosphorylation of Syk kinase. RBL-2H3 cells were sensitized with anti-DNP IgE (0.1μg mL-1) for 1 hr before being treated with DNP-BSA Ag (1μg mL-1) ± 750 ppb As for 5 min. Phosphorylation of Syk was measured with a PathScan ® Phospho-Syk (panTyr) Sandwich ELISA Kit. Values are expressed as % increase over spontaneous (no Ag) control samples and represent mean ± SEM of four experiments, each of triplicate samples. Statistical significance was determined by one sample t-test; *p<0.05