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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Pediatr Dev Pathol. 2017 Jan-Feb;20(1):16–27. doi: 10.1177/1093526616686244

Figure 2. LGR5 expression in pediatric liver diseases.

Figure 2

LGR5 immunolocalization in alpha-1 antitrypsin deficiency (A), acute hepatic necrosis (B), biliary atresia (C), and progressive intrahepatic familial cholestasis (D). Note intense periseptal and peri-portal distribution in regenerative nodules (A) and markedly reduced expression in acute hepatic necrosis (B). Semi-quantitative scoring is shown for LGR5+ hepatocytes (E) versus biliary epithelial cells (F) in alpha-1 antitrypsin deficiency (A1ATD, n = 15), biliary atresia (BA, n = 4), progressive familial intrahepatic cholestasis (PFIC, n = 10), and acute hepatic necrosis (AHN, n = 7).