Figure 4.

HIV-specific CD4 T-cell responses follow-up in untreated and ART-treated patient with PHI. Frequencies of HIV-1 gag-p24-specific IFN-γ⁺ (A) and IL-2⁺ (B) CD4 T cells in patients at baseline (BL) and month 6 of follow-up (M6) in both untreated patients and patients receiving ART after enrollment. Wilcoxon rank tests were performed and p-values are indicated between time points. (C) The frequency of HIV-1 gag-p24-specific IFN-γ⁺ CD4 T cells at month 6 of follow-up in treated patients was correlated to the time interval between estimated date of infection and treatment initiation. The Spearman’s rank correlation coefficient (R) and corresponding p-value are indicated.