FIGURE 4.

Pattern comparison in the NCI-60 cell lines to significant drug correlation using as an input Vemurafenib and BRAF mutation. (A) The table displays NSC, names and FDA status for the top eight compounds highly correlated to Vemurafenib activity. (B) The bar graphs shows the “Z-score determination” for the top three compounds: Vemurafenib, Dabrafenib and NSC 656082, respectively. Most of cell lines harboring BRAF^{V 600E} mutation responded positively to Vemurafenib and Dabrafenib. The cell line responses were distinctly different to NSC 656082 compound.