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. 2016 Sep 29;7:312. doi: 10.3389/fphar.2016.00312

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Copyright © 2016 Belizário, Sangiuliano, Perez-Sosa, Neyra and Moreira.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Connectivity Map portal retrieval. The figure shows barview icons of a query to interrogate potential relationship between the mRNA expression profiles induced by Dermcidin (DCD) and those induced by drugs and small molecules of CMAP database. The barview icons were constructed using 4,217 instances, each representing an individual treatment instance. The results were ordered by their corresponding connectivity scores and p levels. The data support the prediction that DCD-induced gene signature is strongly correlated with signatures induced with small molecules LY-294002, wortmannin and sirolimus, which are potent inhibitors of PI3K, AKT and mTOR signaling pathways, respectively. The chemical structures were obtained from ChemBank. The figure was reproduced with the permission from Moreira et al. (2008).