FIG. 1. Schematic depiction of Salmonellae-mediated cancer therapy. Attenuated S. typhimurium could be used as a delivery vector to achieve local expression of cargo molecules for cancer therapy. When bacteria are administrated to tumor-bearing animals, the bacterial components recognized by pattern recognition receptors (PRRs) or endogenous danger signals activate the inflammasome pathway, resulting in the secretion of proinflammatory cytokines and inducing cancer cell death. DAMPs: damage-associated molecular patterns, PAMPs: pathogen-associated molecular patterns, TLRs: toll-like receptors.
