Isoprenoid pathway organization in Staphylococcus. (a) Schematic showing enzymes (italics) and intermediates (colored ovals) in the mevalonate (blue) and nonmevalonate (red) pathways. (b) A summary of pathway genes present (indicated by check marks) in Staphylococcus species, determined using the KEGG database. (c) Chromosomal location of the mevalonate (blue triangles) and nonmevalonate (red triangles) genes in staphylococcal genomes are shown. The genomes are presented as linear chromosomes oriented such that 0 Mbp is the origin of replication. S. aur, S. aureus; S. epi, S. epidermidis; S. lugd, S. lugdunensis; S. pseud, S. pseudintermedius; S. schl, S. schleiferi.