Fig. 1.

Changes from baseline in SIB total score in study 326 (A) and subanalysis of study 326 (B) in the Asian population. * Donepezil 23 mg; ^† donepezil 10 mg; ^‡ p < 0.05 between treatment groups; ^§ p < 0.001 between treatment groups; ^‖ p < 0.01 between treatment groups. LOCF = Last observation carried forward; LS = least square; LSM = least square mean; SE = standard error; SIB = Severe Impairment Battery. A Reprinted from Farlow et al. [10] with permission from Elsevier. B Reprinted from Han et al. [23] (Copyright© 2016 John Wiley & Sons A/S).