Table 2.
IRRs for Alzheimer's dementia in individuals with an offspring with schizophrenia, other psychiatric service contact, bipolar disorder, other affective disorder or personality disorder compared to individuals with an offspring without psychiatric service contact
| Offspring's mental history | Casesa | Person-years | IRR (95% CI)b | IRR (95% CI)c | IRR (95% CI)d |
|---|---|---|---|---|---|
| Schizophrenia | 417 | 523,179.86 | 1.10 (1.00–1.21) | 1.09 (0.99–1.20) | 0.97 (0.88–1.07) |
| Bipolar disorder | 29 | 26,731.51 | 1.12 (0.76–1.57) | 1.09 (0.74–1.54) | 0.99 (0.67–1.39) |
| Other affective disorder | 244 | 252,733.53 | 1.18 (1.04–1.34) | 1.16 (1.02–1.31) | 1.07 (0.94–1.22) |
| Personality disorder | 167 | 221,764.22 | 1.21 (1.03–1.40) | 1.18 (1.01–1.37) | 1.08 (0.92–1.25) |
| Other psychiatric contact | 1,425 | 1,898,709.24 | 1.13 (1.06–1.19) | 1.11 (1.05–1.17) | 1.05 (0.99–1.11) |
| No psychiatric contact | 10,208 | 22,224,723.71 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
a
Number of individuals with Alzheimer's dementia.
b
Adjusted for calendar year, place of birth, sex and its interaction with age.
c
Further adjustment for somatic comorbidity.
d
Further adjustment for the individuals’ mental disorders.