Table 1.
Clinical studies using HCT for hematopoietic and non-hematopoietic conditionsa
| Disease | Number of trails | North America | EU | Others | Phase 1 | Phase 1/2 | Phase 2 | Phase 2/3 | Phase 3 | Phase 4 | Recruiting and active | Terminated/withdrawn/suspended | Completed |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Leukemia/MDS/hematologic neoplasms | 1, 260 | 912 | 252 | 98 | 179 | 144 | 554 | 21 | 125 | 18 | 542 | 162 | 471 |
| Nonmalignant blood disease | 45 | 36 | 3 | 6 | 11 | 11 | 14 | 2 | 27 | 7 | 11 | ||
| Autoimmune disease | 24 | 25 | 4 | 5 | 8 | 9 | 5 | 1 | 13 | 8 | 2 | ||
| Solid tumors | 19 | 27 | 1 | 1 | 7 | 7 | 6 | 3 | 10 | ||||
| Metabolic disorders | 26 | 22 | 5 | 10 | 7 | 8 | 8 | 3 | 16 | 2 | 8 | ||
| Hepatic disease | 15 | 2 | 2 | 12* | 3 | 3 | 4 | 1 | 9 | 2 | 3 | ||
| Neurologic disease | 54 | 27 | 5 | 32* | 19 | 15 | 11 | 1 | 34 | 4 | 15 | ||
| Cardiac disease | 67 | 14 | 33 | 20* | 9 | 12 | 23 | 9 | 7 | 32 | 8 | 27 |
Listed are studies concerning transplantation/infusion of hematopoietic stem and progenitor cells or purified or non-purified cells derived from peripheral blood, bone marrow or cord blood. Numbers which do not add up to the total number of listed trials, are caused by missing information (e.g. phase or status) in the clinicaltrial.gov database. All categories of clinical trials were analyzed as described above. Except for the category ‘Leukemia/MDS/neoplasm', search results for each category were verified by manual analysis. Analyzed were clinical trials started from 1987 till 2016. (Date of analysis: 15.02.2016).
Mostly Asia (Liver 8/12; Heart 14/20; Neuro 31/32).