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. 2016 Sep 29;6:34199. doi: 10.1038/srep34199

Figure 3. Mst1 overexpression aggravates cardiac microvessel disorder and cardiac dysfunction in diabetic mice.

Figure 3

(A) Tg-Mst1 mice exhibited aggravated cardiac microvessel disorder evaluated by scanning electron microscopy (n = 5) (Magnification: upper panel x10,000; lower panel x5,000); (B) Representative M-mode echocardiograms (n = 6); (C) Representative mitral flow patterns from pulsed Doppler (n = 6); (D,E) LVEF and LVFS measurements; (F,G) LVESD and LVEDD measurements; (H,I) Hemodynamic evaluation of ±LV dp/dt max (n = 5); (J) Mitral valve E velocity; (K) Mitral valve A velocity; (L) Quantification of E/A ratio. LVEF, left ventricular ejection fraction; LVFS, left ventricular fraction shortening; LVESD, left ventricular end-systolic dimension; LVEDD, left ventricular end-diastolic dimension. The columns and error bars represent means and SE. *P < 0.05 vs NTg; #P < 0.05 vs Tg-Mst1; §P < 0.05 vs DM + NTg.