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. 2016 Sep 9;8(9):85. doi: 10.3390/cancers8090085

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Sensing unit of the integrated platform. (a) Schematic showing the ion-exchange nanomembrane sensor; (b) Current-voltage characteristics (CVC) showing changes in ohmic, limiting and overlimiting regions for bare anion-exchange membrane (AEM; black), membrane functionalized with oligoprobe (red) and hybridization of DNA/RNA with oligoprobe (blue); (c) The specificity of the sensor was challenged by using a non-target sequence differing by only two base pairs compared to the target sequence. Change in CVC was only observed for the target miR sequence indicating the sensor’s capability to distinguish two-base-pair mismatches. Adapted with permission from [195].