Table 1.
Particle size (Z-av), polydispersity index (PDI), zeta potential (ζ) and loading efficiency (LE) of trimethyl chitosan (TMC) nanoparticles (NPs) with or without pDNA (n = 3). pDNA/TMC-NPs were either prepared with constant TMC nanoparticles and varying pDNA concentrations or with fixed pDNA concentration and variable amounts of TMC nanoparticles.
| Sample Name | Fixed TMC-NP Concentration | Fixed pDNA Concentration | ||||
|---|---|---|---|---|---|---|
| Z-av (nm) | PDI | ζ (mV) | Z-av (nm) | PDI | ζ (mV) | |
| TMC-NPs unloaded | 527 ± 17 | 0.3 | 10 ± 1 | |||
| pDNA/TMC-NPs-0.07 | 684 ± 107 | 0.3 | 2 ± 0.4 | 712 ± 58 | 0.3 | 1 ± 1 |
| pDNA/TMC-0.7 | 406 ± 3 | 0.3 | −24 ± 2 | 436 ± 14 | 0.3 | −23 ± 3 |
| pDNA/TMC-3 | 485 ± 8 | 0.4 | −28 ± 2 | 401 ± 20 | 0.3 | −30 ± 3 |
| pDNA/TMC-7 | 652 ± 26 | 0.4 | −36 ± 1 | 519 ± 8 | 0.4 | −22 ± 4 |