Table 2. NS8593 delays developmental progression of mouse WT CD1 zygotes prior to the morula stage.
Treatment | #2nd PB/2PNa | #2-Cells (%)b | #4-cells (%) | #8 -cells (%) |
---|---|---|---|---|
Control | 32 | 26 (81) | 26 (100) | 21 (81) |
NS8593-10 μM | 35 | 31 (88) | 21 (69) | 6 (29) |
aZygotes were collected 15 h post hCG. Two replicates, PB: Polar Body, PN: Pro-Nucleus.
b2-cell embryos were evaluated at 24 h post collection, 4-cell embryos at 48 h and 8-cell embryos at 72 h.