Table 2. Association of the methylation at cg17007365 located in the human bace-1 promoter with decline in cognition.
| Parameter Estimate | Std Error | p-value | |
|---|---|---|---|
| Global cognition | −0.0118 | 0.0050 | 0.0182* |
| Episodic memory | −0.0135 | 0.0055 | 0.0151* |
| Semantic memory | −0.0171 | 0.0064 | 0.0078* |
| Working memory | −0.0069 | 0.0048 | 0.1533 |
| Processing speed | −0.0139 | 0.0057 | 0.0148* |
| Visuospatial ability | −0.0087 | 0.0050 | 0.0788 |
The estimate represents the change in cognitive function with one unit increase in methylation. Estimates, standard errors, and p-values at each row came from separate linear mixed models with annual cognitive measures as the longitudinal outcomes and DNA methylation as the predictor, adjusted for age, sex, education, bisulfite conversion efficiency and batch.