Table 1.
Media metabolites with significant temporal trends from 0–48 h.
| OPLS-DA Model (Pre- and Post-Time Shift) | OPLS Model (Time-Dependent) | ||||
|---|---|---|---|---|---|
| Metabolite | VIP | P (loadings) | Metabolite | VIP | P (loadings) |
| Glutamine | 1.42 | −0.28 | Glutamine | 1.37 | −0.25 |
| Glucose | 1.28 | −0.25 | |||
| Serine | 1.20 | −0.24 | Serine | 1.08 | −0.19 |
| Threonine | 1.06 | −0.21 | Cis-Aconitate | 1.10 | −0.22 |
| Methionine | 1.06 | −0.20 | |||
| Choline | 1.05 | −0.17 | Choline | 1.36 | −0.27 |
| Glycine | 1.06 | 0.15 | Glycine | 1.25 | 0.25 |
| Glutamate | 1.06 | 0.22 | Glutamate | 1.17 | 0.22 |
| Methylguanidine | 1.17 | 0.22 | Methylguanidine | 1.35 | 0.27 |
| Alanine | 1.33 | 0.24 | Alanine | 1.55 | 0.30 |
| Acetate | 1.37 | 0.26 | Acetate | 1.55 | 0.31 |
| Lactate | 1.41 | 0.26 | Formate | 1.60 | 0.31 |
| Formate | 1.53 | 0.30 | Lactate | 1.61 | 0.32 |